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Mupirocin

Cat. No. M5124
Mupirocin Structure
Synonym:

BRL-4910A

Size Price Availability Quantity
10mM*1mL in DMSO USD 55  USD55 In stock
10mg USD 50  USD50 In stock
50mg USD 145  USD145 In stock
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Quality Control & Documentation
Biological Activity

Mupirocin is a natural crotonic acid derivative extracted from Pseudomonas fluorescens. Mupirocin inhibits bacterial protein synthesis by specific reversible binding to bacterial isoleucyl tRNA synthase. With excellent activity against gram-positive staphylococci and streptococci, it is primarily used for treatment of primary and secondary skin disorders, nasal infections, and wound healing. Mupirocin is a topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.

Chemical Information
Molecular Weight 500.62
Formula C26H44O9
CAS Number 12650-69-0
Solubility (25°C) DMSO: 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Masoud Dadashi, et al. Mupirocin resistance in Staphylococcus aureus: A systematic review and meta-analysis

[2] Alexandra Tucaliuc, et al. Mupirocin: applications and production

[3] T Poovelikunnel, et al. Mupirocin resistance: clinical implications and potential alternatives for the eradication of MRSA

[4] Jean B Patel, et al. Mupirocin resistance

[5] No authors listed. Drug Ther Bull. Mupirocin nasal ointment

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