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MRTX849 acid can be used to synthesize PROTAC LC-2. LC-2 is a potent, first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50, between 0.25 and 0.76 μM).
| Molecular Weight | 662.15 |
| Formula | C34H37ClFN7O4 |
| CAS Number | 2561529-96-0 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Mark M Awad, et al. N Engl J Med. Acquired Resistance to KRASG12C Inhibition in Cancer
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