MQAE is a fluorescent indicator that is quenched via collision with chloride, and is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells.
|Solubility (25°C)||Water 90 mg/mL
DMSO ≥ 35 mg/mL
|Storage||2-8°C, protect from light, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Sang-Hyun Park, et al. Anal Chem. Mitochondrial Cl --Selective Fluorescent Probe for Biological Applications
 Yukiko Ikeuchi, et al. J Physiol Sci. Measurement of [Cl -] i unaffected by the cell volume change using MQAE-based two-photon microscopy in airway ciliary cells of mice
 Yury Kovalchuk, et al. Cold Spring Harb Protoc. Two-photon chloride imaging using MQAE in vitro and in vivo
 Verena Keitel, et al. Dig Dis. TGR5 in the biliary tree
 Charlotte Andersson, et al. Microsc Res Tech. Determination of chloride efflux by X-ray microanalysis versus MQAE-fluorescence
|Related Fluorescent Dye Products|
Mito Red is a cell membrane permeable rhodamine based dye. It localizes mitochondria, and emits red fluorescence. λex 569 nm; λem 594 nm in DMSO
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase.
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase.
5(6)-FAM SE is an amine-reactive green fluorescent dye widely used for labeling proteins or other molecules that contain a primary or secondary aliphatic amine.
5-FAM SE is a green fluorescent labeling reagent used for labeling peptides, proteins and nucleotides. 5-FAM SE can react with amines and can yield stable amine conjugates.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.