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MOG (35-55) (Mouse, rat)

Cat. No. M10195
MOG (35-55) (Mouse, rat)   Structure
Synonym:

Myelin Oligodendrocyte Glycoprotein (35-55) (Mouse, rat)

Size Price Availability Quantity
1mg USD 125  USD125 In stock
5mg USD 265  USD265 In stock
10mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

MOG (35-55) (Mouse, rat)   is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination.

Chemical Information
CAS Number 149635-73-4 (free base)
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Guang-Xian Zhang, et al. J Neuroimmunol. T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6 x SJL) F1 mice

[2] M Ichikawa, et al. J Immunol. Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55

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