MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE).*The compound is unstable in solutions, freshly prepared is recommended
 |
Source | J Control Release (2018). Figure 2. MMAF |
| Method | MTT assay | |
| Cell Lines | SK-MEL 2 cells | |
| Concentrations | 1 nM | |
| Incubation Time | 120 h | |
| Results | All together, these observations show that EV20/MMAF is endowed with a potent and target-dependent cell killing activity. |
| Molecular Weight | 731.96 |
| Formula | C39H65N5O8 |
| CAS Number | 745017-94-1 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Anthony Markham. Belantamab Mafodotin: First Approval
[5] Aminata Tour, et al. The genetic architecture of morphological abnormalities of the sperm tail
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