Free shipping on all orders over $ 500

Misetionamide

Cat. No. M25461
Misetionamide Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Misetionamide is an orally glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with antineoplastic activity. Misetionamide (0-2000 μM; 12 h) inhibits TNBC cells proliferation. Misetionamide (250-1000 μM; 18 h) induces cell death by a ROS-dependent mechanism in TNBC cells.

Chemical Information
Molecular Weight 137.16
Formula C3H7NO3S
CAS Number 856785-75-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related Apoptosis Products
Peplomycin

Peplomycin is a peptide polyene compound derived from Streptomyces and a Bleomycin analog with high antitumor activity. In addition, Peplomycin induces a variety of skin abnormalities and induces apoptosis in oral squamous carcinoma SSCKN cells and lung fibrosis.

Astin B

Astin B is a orally active and potent cyclic pentapeptide, that has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression.

Lobetyol

Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity.

β-Ionone

β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity.

Uvarigrin

Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation.

  Catalog
Abmole Inhibitor Catalog




Keywords: Misetionamide supplier, Apoptosis, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.