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Mimosine is a known chelator of Fe(III), induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells. Mimosine can act as an antioxidant by its potent iron-binding activity. L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. It is an iron chelator that inhibits DNA replication in mammalian cells. L-Mimosine has been shown to promote apoptosis in xenotransplanted human pancreatic cancer. L-Mimosine stabilizes hypoxia inducible factor 1 (HIF-1) and stimulates the expression of B-cell translocation gene 2 (Btg2) and N-myc downstream regulated gene 1 (Ndrg1) at the transcriptional level, which reduce cell proliferation of prostate carcinoma cells in vitro. L-Mimosine stabilizes HIF-1 through the inhibition of prolyl hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity. Mimosine inhibits cell cycle progression via iron chelation in MDA-MB-453 human breast cancer cells. Mimosine, hinder folate metabolism in cell-specific manner.
| Molecular Weight | 198.18 |
| Formula | C8H10N2O4 |
| CAS Number | 500-44-7 |
| Form | Solid |
| Solubility (25°C) | Water 4 mg/mL (ultrasonic and adjust pH to 2 with HCl and warming) |
| Storage | 4°C, protect from light |
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