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Menadiol

Cat. No. M22516
Menadiol Structure
Synonym:

Dihydrovitamin K3

Size Price Availability Quantity
10mg USD 60  USD60 In stock
25mg USD 120  USD120 In stock
50mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Menadiol (Dihydrovitamin K3), a menaquinol analogue, is an electron donor for reversed oxidative phosphorylation in submitochondrial particles.

Chemical Information
Molecular Weight 174.2
Formula C11H10O2
CAS Number 481-85-6
Solubility (25°C) DMSO 90 mg/mL
Storage 4°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] B Green, et al. Aliment Pharmacol Ther. Phytomenadione or menadiol in the management of an elevated international normalized ratio (prothrombin time)

[2] R Giordani, et al. Eur J Biochem. Kinetics of membrane-bound nitrate reductase A from Escherichia coli with analogues of physiological electron donors--different reaction sites for menadiol and duroquinol

[3] W V Taggart, et al. Biochim Biophys Acta. Menadiol as an electron donor for reversed oxidative phosphorylation in submitochondrial particles

[4] Y Z Su, et al. Cancer Treat Rep. Selective enhancement by menadiol of in vitro drug activity in human lymphatic neoplasms

[5] A Dikow, et al. Histochemistry. Menadiol diphosphate, a new substrate for non-specific alkaline phosphatase in histochemistry and immunohistochemistry

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Keywords: Menadiol, Dihydrovitamin K3 supplier, Vitamin, inhibitors, activators


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