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Menadiol Diacetate

Cat. No. M20431
Menadiol Diacetate Structure
Synonym:

Vitamin K4, Acetomenaphthone, Kapilin

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Biological Activity

Menadiol Diacetate (Vitamin K4) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It induces caspase-3-related apoptosis pathway via mitochondrial dysfunction and DNA fragmentation.

Chemical Information
Molecular Weight 258.27
Formula C15H14O4
CAS Number 573-20-6
Solubility (25°C) DMSO 51 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sajjad Hassan Askari, et al. Environ Sci Pollut Res Int. Menadione sodium bisulfite alleviated chromium effects on wheat by regulating oxidative defense, chromium speciation, and ion homeostasis

[2] Y ASAHI. J Vitaminol (Kyoto). Polarographic determination of ascorbic acid, riboflavin, pteroylglutamic acid, 2-methyl-1,4-naphthohydroquinone diacetate, thiamine, niacinamide and thiamine propyl disulfide in multivitamin preparations

[3] B Lotti. Boll Chim Farm. [Identification and colorimetric determination of menadiol diacetate]

[4] A Dikow, et al. Acta Histochem. Histochemical demonstration of non-specific esterases and non-specific acid phosphatases using menadiol substrates

[5] J Gropp, et al. Z Ernahrungswiss. [Comparison of the biological activity and stability of menadione and menadiol in male chickens]

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Keywords: Menadiol Diacetate, Vitamin K4, Acetomenaphthone, Kapilin supplier, Vitamin, inhibitors, activators

 
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