MAGLi 432 is a novel, reversible inhibitor of monoacylglycerol lipase (MAGL). MAGLi 432 binds with high affinity to the MAGL active site with IC50 values of 4.2 nM (human enzyme) and 3.1 nM (mouse enzyme).
Molecular Weight | 463.80 |
Formula | C22H24BrClN2O2 |
CAS Number | 2361575-20-2 |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related MAGL Products |
---|
ABC34
ABC34 is an inactive control compound of JJH260. |
Dimepiperate
Dimepiperate (MY 93) is a thiocarbamate (TC) pesticide. |
WWL123
WWL123, a carbamate-based compound, is a potent and selective ABHD6 inhibitor. |
DH-376
DH-376 is a potent diacylglycerol lipase inhibitor with pIC50 values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. |
MAGL-IN-5
MAGL-IN-5 (CAY10499) is a non-selective lipase inhibitor with IC50 values of 144, 90, and 14 nM for human recombinant monoacylglycerol lipase(MAGL),hormone sensitive lipase(HSL), and fatty acid amide hydrolase(FAAH) respectively. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.