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Lucifer Yellow CH dilithium salt

Cat. No. M13790
Lucifer Yellow CH dilithium salt Structure
Size Price Availability Quantity
25mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Lucifer Yellow CH dilithium salt is a highly fluorescent dye that is useful in marking nerve cells. Lucifer Yellow CH dilithium salt is assumed to be nontoxic, and it is membrane impermeable and highly dissociated at physiological pH values.

Chemical Information
Molecular Weight 457.25
CAS Number 67769-47-5
Solubility (25°C) Water 25 mg/mL (ultrasonic and warming and heat to 60°C)
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Baochang Qi, et al. J Exp Clin Cancer Res. Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate

[2] Doerte Luensmann, et al. Curr Eye Res. Localization of lysozyme sorption to conventional and silicone hydrogel contact lenses using confocal microscopy

[3] S J Hill, et al. J Neurosci Methods. Visualization of neurons filled with biotinylated-lucifer yellow following identification of efferent connectivity with retrograde transport

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