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Lucatumumab

Cat. No. M25275

All AbMole products are for research use only, cannot be used for human consumption.

Lucatumumab Structure
Synonym:

HCD122

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Quality Control & Documentation
Biological Activity

Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research.

Chemical Information
CAS Number 903512-50-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Guoxu Fang, et al. Cancer Lett. Inhibition of GSK-3β activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling

[2] Marius Stiefelhagen, et al. Leuk Lymphoma. Activity of the CD40 antagonistic antibody lucatumumab - insights from CLL-niche mimicking xenografts and fludarabine combinations

[3] John C Byrd, et al. Leuk Lymphoma. Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia

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Keywords: Lucatumumab, HCD122 supplier, TNF Receptor, inhibitors, activators

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