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Lauric acid

Cat. No. M10341
Lauric acid Structure
Size Price Availability Quantity
10g USD 30  USD30 In stock
25g USD 40  USD40 In stock
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Quality Control & Documentation
Biological Activity

Lauric acid is a middle chain-free fatty acid with strong bactericidal properties.

Chemical Information
Molecular Weight 200.32
Formula C12H24O2
CAS Number 143-07-7
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Teruaki Nakatsuji, et al. J Invest Dermatol. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris

[2] M T Ryan, et al. Biochim Biophys Acta. The paradoxical effect of fatty acid on steroid-albumin interaction

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