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Labetuzumab govitecan

Cat. No. M24697

All AbMole products are for research use only, cannot be used for human consumption.

Labetuzumab govitecan Structure
Synonym:

IMMU 130 hMN-14-SN-38

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100ug USD 420  USD420 In stock
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Biological Activity

Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer.

Chemical Information
CAS Number 1469876-18-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Diana C DeLucia, et al. Clin Cancer Res. Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drυg Conjugate in Neuroendocrine Prostate Cancer

[2] Wenjuan Dong, et al. Eur J Med Chem. Antibody-drυg conjugates of 7-ethyl-10-hydroxycamptothecin: Sacituzumab govitecan and labetuzumab govitecan

[3] Robert M Sharkey, et al. Mol Cancer Ther. Selective and Concentrated Accretion of SN-38 with a CEACAM5-Targeting Antibody-Drυg Conjugate (ADC), Labetuzumab Govitecan (IMMU-130)

[4] Manjulika Das. Lancet Oncol. Labetuzumab govitecan in metastatic colorectal cancer

Related Drug-Linker Conjugates for ADC Products
MC-SN38 

MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC).
DM4-SMCC 

DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker.
Lys-SMCC-DM1

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization.
Doxorubicin-SMCC 

Doxorubicin-SMCC is a agent-linker conjugate for ADC.
Mal-PEG4-VC-PAB-DMEA-PNU-159682 

Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682.
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Keywords: Labetuzumab govitecan, IMMU 130 hMN-14-SN-38 supplier, Drug-Linker Conjugates for ADC, inhibitors, activators

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