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CL2A-SN-38

Cat. No. M9655
CL2A-SN-38 Structure
Synonym:

CL2A-SN38

Size Price Availability
5mg USD 978  USD978 4-7 Days
10mg USD 1496  USD1496 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

CL2A-SN-38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an ADC. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make ADC. CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond.

NOTE: CL2A-SN-38 free base is less stable.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1480.61
Formula C73H97N11O22
CAS Number 1279680-68-0
Purity >98.5%
Solubility DMSO ≥ 50 mg/mL
Storage -20°C, dry, sealed, protect from light
References

[1] Thomas M Cardillo, et al. Clin Cancer Res. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CL2A-SN-38, CL2A-SN38 supplier, inhibitors

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