Free shipping on all orders over $ 500

BS3 (bis(sulfosuccinimidyl)suberate)

Cat. No. M9872

All AbMole products are for research use only, cannot be used for human consumption.

BS3 (bis(sulfosuccinimidyl)suberate) Structure
Synonym:

BS3 Crosslinker

Size Price Availability Quantity
5mg USD 36  USD36 In stock
10mg USD 58  USD58 In stock
25mg USD 108  USD108 In stock
100mg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

BS3 (bis(sulfosuccinimidyl)suberate) is an interamino acid crosslinker that is water soluble, non-cleavable, and membrane impermeable and is used in the synthesis of antibody coupled drugs (ADCs).

Applications:

- Crosslinking of cell surface proteins prior to cell lysis and immunoprecipitation.

- Identification of receptor ligand interactions by chemical cross-linking

- Identify weak or transient protein interactions by "immobilizing" them

- Identification of neighboring protein interactions

- Protein cross-linking in a one-step reaction to obtain biocouplings

- Immobilization of proteins on amino-coated surfaces

Product Citations
Chemical Information
Molecular Weight 572.43
Formula C16H18N2O14S2Na2
CAS Number 82436-77-9
Solubility (25°C) Water ≥ 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Camilla De Nardis, et al. J Biol Chem. Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP)

[2] Maarten van Dinther, et al. PLoS One. Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling

[3] Mairi L Kilkenny, et al. J Biol Chem. A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome

Related Drug-Linker Conjugates for ADC Products
MC-SN38 

MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC).
DM4-SMCC 

DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker.
Lys-SMCC-DM1

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization.
Doxorubicin-SMCC 

Doxorubicin-SMCC is a agent-linker conjugate for ADC.
Mal-PEG4-VC-PAB-DMEA-PNU-159682 

Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682.
  Catalog
Abmole Inhibitor Catalog




Keywords: BS3 (bis(sulfosuccinimidyl)suberate), BS3 Crosslinker supplier, Drug-Linker Conjugates for ADC, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.