All AbMole products are for research use only, cannot be used for human consumption.
L82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM).
L82 (0-50 μM; 6 d) shows anti-proliferative activity to breast cancer cells. L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells.
| Molecular Weight | 309.67 |
| Formula | C11H8ClN5O4 |
| CAS Number | 329227-30-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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