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L-NIO dihydrochloride

Cat. No. M14100
L-NIO dihydrochloride Structure
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Biological Activity

L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats.

Chemical Information
Molecular Weight 246.13
CAS Number 159190-44-0
Solubility (25°C) Water 90 mg/mL
DMSO 33.33 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Emma Mitidieri, et al. Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity

[2] Tijen Kaya Temiz, et al. Effect of nitrergic system on colonic motility in a rat model of irritable bowel syndrome

[3] Joana B Sousa, et al. Endothelial dysfunction impairs vascular neurotransmission in tail arteries

[4] Ahmet Altun, et al. Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination

[5] Zhelong Xu, et al. Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes

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Keywords: L-NIO dihydrochloride supplier, NOS, inhibitors, activators


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