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L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats.
| Molecular Weight | 246.13 |
| CAS Number | 159190-44-0 |
| Solubility (25°C) | Water 90 mg/mL DMSO 33.33 mg/mL |
| Storage | -20°C, dry, sealed |
| Related NO Synthase Products |
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| (S)-ZLc002
(S)-ZLc002 is a S-enantiomer of ZLc-002. |
| GW274150
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). |
| NOS-IN-1
NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively. |
| ARL 17477
ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers. |
| NOS1-IN-1
NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. |
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