L-NIL

Cat. No. M14099

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Quality Control

Current batch:
Purity >99%
COA
MSDS

Product Information

Biological Activity

L-NIL is an inducible NO synthase inhibitor, with an IC₅₀ of 3.3 μM for miNOS.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information

Molecular Weight	187.24
Formula
CAS Number	53774-63-3
Purity	>99%

Solubility	Water 50 mg/mL
Storage	-20°C, dry, sealed

References

[1] David G Leach, et al. Biomaterial-Facilitated Immunotherapy for Established Oral Cancers

[2] Aurelie Hanoteau, et al. Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

[3] Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice

[4] Fabian Arnberg, et al. L-N-iminoethyl-lysine after experimental brain trauma attenuates cellular proliferation and astrocyte differentiation

[5] Matthieu Legrand, et al. L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats

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Product Type

L-NIL

Quality Control

Biological Activity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Chemical Information

References

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