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L-NIL

Cat. No. M14099
L-NIL Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 187.24
Formula
CAS Number 53774-63-3
Purity >99%
Solubility Water 50 mg/mL
Storage -20°C, dry, sealed
References

[1] David G Leach, et al. Biomaterial-Facilitated Immunotherapy for Established Oral Cancers

[2] Aurelie Hanoteau, et al. Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

[3] Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice

[4] Fabian Arnberg, et al. L-N-iminoethyl-lysine after experimental brain trauma attenuates cellular proliferation and astrocyte differentiation

[5] Matthieu Legrand, et al. L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats

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Keywords: L-NIL supplier, NOS, inhibitors

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