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L-ANAP hydrochloride 

Cat. No. M25554
L-ANAP hydrochloride  Structure
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Biological Activity

L-ANAP hydrochloride is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).

Chemical Information
Molecular Weight 308.76
Formula C15H17ClN2O3
CAS Number 1313516-26-5 (free base)
Form Solid
Solubility (25°C) DMSO 30 mg/mL
Water 1 mg/mL (Need ultrasonic)
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Priyanka Baloni, et al. Commun Biol. Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease

[2] Martina Klünemann, et al. Nature. Bioaccumulation of therapeutic drυgs by human gut bacteria

[3] Leonie Hennissen, et al. CNS Drugs. Cardiovascular Effects of Stimulant and Non-Stimulant Medication for Children and Adolescents with ADHD: A Systematic Review and Meta-Analysis of Trials of Methylphenidate, Amphetamines and Atomoxetine

[4] Noha N Nassar, et al. J Adv Res. Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review

[5] Junichi Ogata, et al. Pharmacology. A forskolin derivative, colforsin daropate hydrochloride, inhibits rat mesangial cell mitogenesis via the cyclic AMP pathway

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