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Kazinol B

Cat. No. M38996
Kazinol B Structure
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Biological Activity

Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research.

Chemical Information
Molecular Weight 392.49
Formula C25H28O4
CAS Number 99624-27-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qian Zhang et al. Pharm Biol. Kazinol B protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced cardiac injury by modulating the AKT/AMPK/Nrf2 signalling pathway

[2] Ji-Young Park et al. J Enzyme Inhib Med Chem. Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

[3] Hyejin Lee et al. Fitoterapia. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes

[4] Jih-Pyang Wang et al. Naunyn Schmiedebergs Arch Pharmacol. Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils

[5] J P Wang et al. Br J Pharmacol. The signal transduction mechanism involved in kazinol B-stimulated superoxide anion generation in rat neutrophils

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Keywords: Kazinol B supplier, NO Synthase, inhibitors, activators

 
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