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JC-171 is a selective inhibitor of NLRP3 inflammasomes that inhibits the release of IL-1β by macrophages induced by LPS/ATP IC50 The value is 8.45 μM.
| Molecular Weight | 384.83 |
| Formula | C16H17ClN2O5S |
| CAS Number | 2112809-98-8 |
| Solubility (25°C) | DMSO ≥ 200 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NLR Products |
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SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. |
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| NBC19
NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. |
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