All AbMole products are for research use only, cannot be used for human consumption.
Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (KD: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases.
| CAS Number | 2031153-61-2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] Luigi Bartalena, et al. J Intern Med. Current concepts regarding Graves' orbitopathy
[2] Bin Wang, et al. BioDrugs. Targeted Therapy for Primary Sjögren's Syndrome: Where are We Now?
[3] Ondrej Viklicky, et al. Curr Opin Organ Transplant. Developments in immunosuppression
[4] Clio P Mavragani, et al. J Autoimmun. Sjögren's syndrome: Old and new therapeutic targets
| Related TNF Receptor Products |
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| Atrosab
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. |
| Mesaconitine
Mesaconitine is the main active ingredient of Aconitum and has many pharmaceutical effects. |
| Hypaconitine
Hypaconitine is a highly toxic natural active ingredient isolated from aconitum species, which is widely used to study rheumatism. |
| Shikonin
Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), Proteasome can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. |
| Forsythoside B
Forsythoside B inhibits TNF-alpha, IL-6, IκB and modulate NF-κB. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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