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Irbesartan (Avapro) belongs to the class of medicines called angiotensin II inhibitor antihypertensives. It is used to treat high blood pressure (hypertension). Irbesartan works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, Irbesartan relaxes blood vessels and lowers blood pressure. [1, 2]
| Cell Experiment | |
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| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | Male Sprague-Dawley rats and female cynomolgus monkeys (Macaca fascicularis) injected (iv) with angiotensin II (AII) |
| Formulation | Dissolved in water by neutralization with a stoichiometric equivalent of KOH, or dissolved in saline by neutralization with a stoichiometric equivalent of L-arginine |
| Dosages | 1 mg/kg |
| Administration | Oral gavage |
| Molecular Weight | 428.53 |
| Formula | C25H28N6O |
| CAS Number | 138402-11-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ibrahim A Darwish, et al. Irbesartan (a comprehensive profile)
[4] Claudio Borghi, et al. The cost-effectiveness of irbesartan for hypertension
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