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IPN-60090 (IACS-6274) is an inhibitor of orally active and highly selective glutaminease 1 GLS1 (IC50=31 nM), inactive against GLS-2. IPN-60090 (IACS-6274) exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 can be used in the study of solid tumors such as lung and ovarian cancers.
| Molecular Weight | 532.52 |
| Formula | C24H27F3N8O3 |
| CAS Number | 1853164-83-6 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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