About 18 results found for searched term "Glutaminase" (0.121 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6285 | Glutaminase C-IN-1 | Glutaminase |
| Compound 968 | ||
| Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts. | ||
| M50281 | Glutaminase | Enzymes & Coenzymes |
| Glutaminase (GLS) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M2548 | Cysteamine hydrochloride | Animal Modeling |
| β-MEA Hydrochloride; β-Mercaptoethylamine Hydrochloride; 2-Aminoethanethiol Hydrochloride | ||
| Cysteamine HCl, the hydrochloride form of Cysteamine, is also a transglutaminase 2 (TGM2) inhibitor, which can be used to induce gastrointestinal disorders in a mouse model as well as a duodenal ulcer model. In addition, Cysteamine HCl has the ability to modulate the activity of dopamine neurons in the striatum of awake, freely moving rats by inhibiting the increased dopamine release from amphetamine, and has antioxidant activity. | ||
| M3003 | CB-839 | GluR |
| Telaglenastat | ||
| CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. | ||
| M3141 | ZM 39923 hydrochloride | JAK |
| ZM 39923 is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. | ||
| M5015 | BPTES | Glutaminase |
| BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. | ||
| M6647 | Cystamine dihydrochloride | Caspase |
| Cystamine dihydrochloride is a transglutaminase inhibitor; neuroprotective. | ||
| M9215 | GK921 | Glutaminase |
| GK921 is a transglutaminase 2 (TGase 2) inhibitor. | ||
| M10745 | 6-Diazo-5-oxo-L-norleucine | Glutaminase |
| 6-Diazo-5-oxo-L-nor-Leucine; L-6-Diazo-5-oxonorleucine; DON | ||
| 6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON) is an antibiotic isolated from Streptomyces, an antagonist of glutaminase with an IC50 value of about 1 mM for cKGA (renal glutamine). 6-Diazo-5-oxo-L-norleucine has analgesic, antibacterial, antiviral and anti-cancer properties. | ||
| M14441 | JHU-083 | Others |
| JHU-083, a precursor of 6-diazo-5-oxo-L-norleucine, is an orally active and selective glutaminase antagonist. | ||
| M20645 | UPGL00004 | GluR |
| UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2. | ||
| M21510 | Telaglenastat hydrochloride | Others |
| CB-839 hydrochloride | ||
| Telaglenastat (CB-839) hydrochloride is a pioneering (first-in-class), selective, reversible, orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride has IC50 values of 23 nM and 28 nM for endogenous glutaminase in the kidney and brain of mice, respectively. Telaglenastat hydrochloride also induces autophagy and has strong antitumor activity. | ||
| M24917 | Zampilimab | Others |
| UCB-7858 | ||
| Zampilimab (UCB-7858) is a monoclonal antibody against transglutaminase 2 (TG2). Zampilimab has potential application in renal transplant, and relevant research is still ongoing. | ||
| M28224 | NC9 | Glutaminase |
| Cbz-Lys(Acr)-PEG2-dansyl | ||
| NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible transglutaminase (TG) inhibitor. NC9 inhibits osteoblast differentiation and mineralization. NC9 destabilizes microtubules. NC9 can be used for the research of osteoblast differentiation. | ||
| M42426 | TG53 | Glutaminase |
| TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. | ||
| M43436 | PROTAC TG2 degrader-1 | PROTAC |
| PROTAC TG2 degrader-1 is a von Hippel-Lindau (VHL)-based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM. | ||
| M43438 | PROTAC TG2 degrader-2 | PROTAC |
| PROTAC TG2 degrader-2 is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. | ||
| M49635 | ZM39923 | JAK |
| ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM. | ||
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