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Insulin degludec

Cat. No. M22472

All AbMole products are for research use only, cannot be used for human consumption.

Insulin degludec Structure
Size Price Availability Quantity
5mg USD 220  USD220 In stock
10mg USD 350  USD350 In stock
25mg USD 680  USD680 In stock
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Quality Control & Documentation
Biological Activity

Insulin degludec is an ultra-long-acting form of insulin, shows binding efficiency with an IC50 value of 19.59 nM/L for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes.

Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells.

In vivo, Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia.

Chemical Information
Molecular Weight 6103.97
Formula C274H411N65O81S6
CAS Number 844439-96-9
Form Solid
Storage -20°C, protect from light, dry, sealed
References

[1] Amalia Gastaldelli, et al. Lancet Diabetes Endocrinol. Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

[2] Tadej Battelino, et al. Lancet Diabetes Endocrinol. Efficacy of once-weekly tirzepatide versus once-daily insulin degludec on glycaemic control measured by continuous glucose monitoring in adults with type 2 diabetes (SURPASS-3 CGM): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

[3] Bernhard Ludvik, et al. Lancet. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial

[4] Ronald M Goldenberg, et al. Diabetes Obes Metab. Effect of insulin degludec versus insulin glargine U100 on time in range: SWITCH PRO, a crossover study of basal insulin-treated adults with type 2 diabetes and risk factors for hypoglycaemia

[5] Roopa Mehta, et al. Diabetes Obes Metab. Practical use of insulin degludec/insulin aspart in a multinational setting: beyond the guidelines

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Keywords: Insulin degludec supplier, Insulin Receptor, inhibitors, activators

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