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Indirubin-3′-oxime

Cat. No. M20836
Indirubin-3′-oxime Structure
Synonym:

IDR3O, I3O

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Biological Activity

Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.

Chemical Information
Molecular Weight 277.28
Formula C₁₆H₁₁N₃O₂
CAS Number 667463-82-3
Solubility (25°C) DMSO 55 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yeong Chan Ryu, et al. Br J Pharmacol. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis

[2] Yasuhito Nobushi, et al. Biol Pharm Bull. Inhibitory Effects of Indirubin-3'-oxime Derivatives on Lipid Accumulation in 3T3-L1 Cells

[3] Ming-Yang Lee, et al. Eur J Pharmacol. Indirubin-3'-oxime suppresses human cholangiocarcinoma through cell-cycle arrest and apoptosis

[4] Jie Yu, et al. Cell Mol Neurobiol. Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway

[5] Ana T Varela, et al. Toxicol Appl Pharmacol. Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction

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Keywords: Indirubin-3′-oxime, IDR3O, I3O supplier, GSK-3, inhibitors, activators

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