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IDE397 (GSK-4362676) is a potent, potential "first-in-class" inhibitor of methionine adenosyltransferase 2A (MAT2A). IDE397 (GSK-4362676) exhibits anti-tumor activity in MTAP-deleted PDX models.
| Molecular Weight | 340.69 |
| Formula | C14H8ClF3N4O |
| CAS Number | 2439277-80-0 |
| Solubility (25°C) | DMSO 18 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Methionine Adenosyltransferase Products |
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| MAT2A-IN-10
MAT2A-IN-10 is an orally active MAT2A inhibitor with an IC50 of 26 nM. |
| MAT2A-IN-12
MAT2A Allosteric inhibitor 2 is a potent and selective MAT2A allosteric inhibitor with an IC50 of 5 nM. |
| MAT2A inhibitor 3
MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor, with an IC50 of <200 nM. MAT2A inhibitor 3 can be used for the research of cancers. |
| MAT2A inhibitor 2
MAT2A inhibitor 2 is a methionine adenosyltransferase 2A (MAT2A) inhibitor. |
| AG-270
AG-270 is a non-competitive, first-of-its-kind, reversible, orally active MAT2A allogeneic inhibitor IC50 The value is 14 nM. |
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