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MAT2A inhibitor 2

Cat. No. M28179

All AbMole products are for research use only, cannot be used for human consumption.

MAT2A inhibitor 2 Structure

Size	Price	Availability	Quantity
1mg	USD 45	In stock
5mg	USD 85	In stock
10mg	USD 130	In stock

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Quality Control & Documentation

Specification: ≥99.0%
COA
MSDS

Product Information

Biological Activity

MAT2A inhibitor 2 is a methionine adenosyltransferase 2A (MAT2A) inhibitor.

Chemical Information

Molecular Weight	365.85
Formula	C18H24ClN3O3
CAS Number	13299-99-5
Form	Solid
Solubility (25°C)	DMSO 75 mg/mL (ultrasonic)
Storage	4°C, dry, sealed

References

[1] Peter Kalev, et al. Cancer Cell. MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage

[2] Cunzhen Zhao, et al. Anim Sci J. MAT2A/2B promote porcine intramuscular preadipocyte proliferation through ERK signaling pathway

[3] Casey L Quinlan, et al. Nat Chem Biol. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

[4] Katya Marjon, et al. Cell Rep. MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

[5] Maddalena Frau, et al. J Hepatol. Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis

Related Methionine Adenosyltransferase Products
PF-9366 PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), with IC50 of 420 nM and Kd of 170 nM.
FIDAS-5 FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.
AG-270 AG-270 is a non-competitive, first-of-its-kind, reversible, orally active MAT2A allogeneic inhibitor IC50 The value is 14 nM.
IDE397 IDE397 (GSK-4362676) is a potent, potential "first-in-class" inhibitor of methionine adenosyltransferase 2A (MAT2A). IDE397 (GSK-4362676) exhibits anti-tumor activity in MTAP-deleted PDX models.

Catalog

Abmole Inhibitor Catalog

Keywords: MAT2A inhibitor 2 supplier, Methionine Adenosyltransferase, inhibitors, activators

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