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FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells. FIDAS-5 (20 mg/kg/day; oral gavage; two weeks) treatment significantly inhibits the growth of xenograft tumors in athymic nude mice, with minimal difference in body weight.
| Molecular Weight | 261.72 |
| Formula | C15H13ClFN |
| CAS Number | 1391934-98-7 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Methionine Adenosyltransferase Products |
|---|
| IDE397
IDE397 (GSK-4362676) is a potent, potential "first-in-class" inhibitor of methionine adenosyltransferase 2A (MAT2A). IDE397 (GSK-4362676) exhibits anti-tumor activity in MTAP-deleted PDX models. |
| MAT2A-IN-10
MAT2A-IN-10 is an orally active MAT2A inhibitor with an IC50 of 26 nM. |
| MAT2A-IN-12
MAT2A Allosteric inhibitor 2 is a potent and selective MAT2A allosteric inhibitor with an IC50 of 5 nM. |
| MAT2A inhibitor 3
MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor, with an IC50 of <200 nM. MAT2A inhibitor 3 can be used for the research of cancers. |
| MAT2A inhibitor 2
MAT2A inhibitor 2 is a methionine adenosyltransferase 2A (MAT2A) inhibitor. |
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Products are for research use only. Not for human use. We do not sell to patients.
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