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FIDAS-5

Cat. No. M10056
FIDAS-5 Structure
Size Price Availability Quantity
10mg USD 245  USD245 In stock
25mg USD 440  USD440 In stock
50mg USD 650  USD650 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells. FIDAS-5 (20 mg/kg/day; oral gavage; two weeks) treatment significantly inhibits the growth of xenograft tumors in athymic nude mice, with minimal difference in body weight.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 261.72
Formula C15H13ClFN
CAS Number 1391934-98-7
Purity >98%
Solubility DMSO 100 mg/mL
Storage at -20°C
References

[1] Wen Zhang, et al. ACS Chem Biol. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A

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Keywords: FIDAS-5 supplier, Wnt/beta-catenin, inhibitors

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