HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.
| Molecular Weight | 317.75 |
| Formula | C13H8ClN5OS |
| CAS Number | 922050-57-5 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] David A Carlson, et al. Cell Chem Biol. Targeting Pim Kinases and DAPK3 to Control Hypertension
| Related Pim Products |
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FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). |
| Pim-1 kinase inhibitor 5
Pim-1 kinase inhibitor 5 is a Pim-1 kinase inhibitor (IC50: 0.61 μM). |
| Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 is a Pim-1 kinase inhibitor (IC50: 17.01 nM). |
| Pim-1 kinase inhibitor 6
Pim-1 kinase inhibitor 6 is a potent Pim-1 kinase inhibitor with IC50 value of 0.46 μM, and has significant cytotoxic effect on cancer cells. |
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