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HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.
| Molecular Weight | 317.75 |
| Formula | C13H8ClN5OS |
| CAS Number | 922050-57-5 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] David A Carlson, et al. Cell Chem Biol. Targeting Pim Kinases and DAPK3 to Control Hypertension
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