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GSK-843 is a potent receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 inhibits TNF/Z-VAD-FMK/IAP agonist-induced cell necrosis in human mice (EC50 range <0.12 to 3 μM). GSK-843 (0.3-3 μM; 18 h) suppresses TNF-induced death and virus-induced cell necrosis.
| Molecular Weight | 377.49 |
| Formula | C19H15N5S2 |
| CAS Number | 1601496-05-2 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | -20°C, sealed |
| Related Necroptosis Products |
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| GW806742X hydrochloride
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