About 15 results found for searched term "Necroptosis" (0.215 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M31123 | Necroptosis-IN-3 | Apoptosis |
| Necroptosis-IN-3, an inhibitor of necroptosis, inhibits TNF-α-induced necroptosis and also inhibits 11β-HSD1. | ||
| M2315 | Necrostatin-1 | RIPK |
| Nec-1 | ||
| Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO. | ||
| M7942 | Necrostatin-5 | RIPK |
| Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. | ||
| M7956 | Necrostatin-7 | Others |
| Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. | ||
| M8758 | GW806742X | Necroptosis |
| GW806742X is an ATP site-targeing kinase inhibitor (IC50 in nM = 2/VEGFR2, 15/SRC, 47/C-FMS, 851/GSK3, 9016/ERBB2, 9120/FGFR) with potent antiproliferation activity against cancer cultures (IC50 in nM = 5/HUVEC-v, 424/HUVEC-b, 81/HEF, 453/MDA468, 470/A375P, 693/HT29, 734/PC3), GW806742X is now better known as Compound 1 for its anti-necroptosis activity via affinity interaction with ML | ||
| M9062 | Necrosulfonamide | Necroptosis |
| NSA | ||
| Necrosulfonamide is a necroptosis inhibitor which selectively targeting the mixed lineage kinase domain-like protein (MLKL) with IC50 value of 124 nM in human HT-29. Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. | ||
| M10287 | GSK547 | Necroptosis |
| GSK'547 | ||
| GSK547 is a potent and highly selective inhibitor of receptor-interacting protein kinase 1 (RIPK1) and also inhibits necroptosis. | ||
| M11195 | CDDO-2-P-Im | Apoptosis |
| CPD1589;CPDB1589 | ||
| Cddo-2p-im is a CDDO imidazolid analogue with chemoprophylaxis. Cddo-2p-im reduced the size and severity of lung tumors in mouse lung cancer models. Cddo-2p-im is an orally active necroptosis inhibitor that can be used in ischemia/reperfusion (I/R) studies. | ||
| M11315 | PK68 | Necroptosis |
| PK68 is a potent and selective type II RIPK1 inhibitor with an IC50 value of approximately 90 nM that inhibits RIPK1-dependent necroptosis. It can be used in studies related to inflammatory diseases and cancer metastasis. | ||
| M13394 | GSK2593074A | RIPK |
| GSK'074 | ||
| GSK2593074A is a necroptosis inhibitor that inhibits RIP1 and 3. | ||
| M13556 | Necrostatin 2 | RIPK |
| Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. | ||
| M14173 | GW806742X hydrochloride | Necroptosis |
| GW806742X hydrochloride is an ATP mimetic and potent inhibitor of MLKL and necroptosis, slowing down MLKL membrane translocation and binding to the MLKL pseudokinase domain with a Kd value of 9.3 μM. GW806742X hydrochloride has anti-VEGFR2 activity (IC50=2 nM). GW806742X hydrochloride has anti-VEGFR2 activity (IC50=2 nM). | ||
| M28293 | T2AA | DNA/RNA Synthesis |
| T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase. | ||
| M29198 | TC13172 | Necroptosis |
| TC13172 is an inhibitor of MLKL and necroptosis that acts on HT-29 cells with an EC50 value of 2 nM. | ||
| M43194 | Cathepsin B | Enzymes & Coenzymes |
| Cathepsin B is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death). | ||
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