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GSK547 is a potent and highly selective receptor-interacting serine/threonine protein kinase 1 (RIPK1) inhibitor. GSK'547 inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. GSK547 up-regulates STAT1 signaling in bone marrow-derived macrophages (BMDM).
| Molecular Weight | 396.39 |
| Formula | C20H18F2N6O |
| CAS Number | 2226735-55-1 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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