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Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis. Necrosulfonamide significantly decreases BV6/DAC-induced cell death in MV4-11 cells. Necrosulfonamide is also an effective inhibitor of the necroptotic pathway induced by STS in the presence of caspase inhibitor.
JACC-BASIC TRANSL SC. 2023 May 31.
PCSK9 Promotes Hypoxia-Induced Endothelial Cell Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia
Necrosulfonamide purchased from AbMole
| Molecular Weight | 461.47 |
| Formula | C18H15N5O6S2 |
| CAS Number | 1360614-48-7 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Bae JH, et al. Arch Pharm Res. Chemical regulation of signaling pathways to programmed necrosis.
| Related Necroptosis Products |
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| TC13172
TC13172 is an inhibitor of MLKL and necroptosis that acts on HT-29 cells with an EC50 value of 2 nM. |
| GW806742X hydrochloride
GW806742X hydrochloride is an ATP mimetic and potent inhibitor of MLKL and necroptosis, slowing down MLKL membrane translocation and binding to the MLKL pseudokinase domain with a Kd value of 9.3 μM. GW806742X hydrochloride has anti-VEGFR2 activity (IC50=2 nM). GW806742X hydrochloride has anti-VEGFR2 activity (IC50=2 nM). |
| GSK-843
GSK-843 is a potent receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. |
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