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GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.
| Molecular Weight | 439.55 |
| Formula | C27H29N5O |
| CAS Number | 1202580-59-3 |
| Form | Liquid |
| Storage | -20°C |
| Related NAMPT Products |
|---|
| JGB-1-155
JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 μM. |
| Nampt activator-2
Nampt activator-2 is a potent NAMPT activator, with EC50 of 0.023 μM. |
| Teglarinad chloride
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). |
| NAMPT degrader-3
NAMPT degrader-3 is a NAMPT degrader, depending on VHL- and proteasome manner. |
| Nampt activator-3
NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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