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P7C3 is an orally bioavailable and blood-brain barrier penetrant aminopropyl carbazole, with neuroprotective effects. P7C3 exerts its proneurogenic activity by protecting newborn neurons from apoptosis. P7C3 also enhances learning and memory in aged rats. P7C3 can be used for the research of neurodegenerative diseases, including Parkinson's disease.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Mice |
| Formulation | Dissolved in DMSO and diluted with 3% DMSO/10% cremophor EL/87.5% D5W (5% dextrose in water, pH 7.2). |
| Dosages | ~40 mg/kg |
| Administration | p.o.; i.p. |
| Molecular Weight | 474.19 |
| Formula | C21H18Br2N2O |
| CAS Number | 301353-96-8 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Pieper AA, et al. Cell. Discovery of a proneurogenic, neuroprotective chemical.
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