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Cat. No. M3144
P7C3 Structure
Size Price Availability Quantity
10mg USD 100  USD100 In stock
50mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

P7C3 is a Proneurogenic, neuroprotective compound. P7C3 Protects newborn neurons in the dentate gyrus and stimulates the growth of new neurons. Also enhances learning and memory in aged rats. Orally available and brain penetrant.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models Mice
Formulation Dissolved in DMSO and diluted with 3% DMSO/10% cremophor EL/87.5% D5W (5% dextrose in water, pH 7.2).
Dosages ~40 mg/kg
Administration p.o.; i.p.
Chemical Information
Molecular Weight 474.19
Formula C21H18Br2N2O
CAS Number 301353-96-8
Solubility (25°C) DMSO: ≥ 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Pieper AA, et al. Cell. Discovery of a proneurogenic, neuroprotective chemical.

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