P7C3 is a Proneurogenic, neuroprotective compound. P7C3 Protects newborn neurons in the dentate gyrus and stimulates the growth of new neurons. Also enhances learning and memory in aged rats. Orally available and brain penetrant.
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Preparation method | |
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Incubation time |
Animal Experiment | |
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Animal models | Mice |
Formulation | Dissolved in DMSO and diluted with 3% DMSO/10% cremophor EL/87.5% D5W (5% dextrose in water, pH 7.2). |
Dosages | ~40 mg/kg |
Administration | p.o.; i.p. |
Molecular Weight | 474.19 |
Formula | C21H18Br2N2O |
CAS Number | 301353-96-8 |
Solubility (25°C) | DMSO: ≥ 25 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Pieper AA, et al. Cell. Discovery of a proneurogenic, neuroprotective chemical.
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