About 15 results found for searched term "NAMPT" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9130 | LSN3154567 | NAMPT |
| Nampt-IN-1 | ||
| LSN3154567 (also known as Nampt-IN-1) is a potent and elective NAMPT inhibitor, inhibits purified NAMPT with an IC50 of 3.1 nM. | ||
| M29654 | Nampt-IN-8 | NAMPT |
| Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS. | ||
| M42529 | Nampt activator-3 | NAMPT |
| NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. | ||
| M42530 | NAMPT degrader-3 | NAMPT |
| NAMPT degrader-3 is a NAMPT degrader, depending on VHL- and proteasome manner. | ||
| M2287 | APO866 | Transferase |
| FK866; Daporinad | ||
| APO866 is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase; NAMPT) with an IC50 of 0.09 nM. | ||
| M3033 | STF-118804 | NAMPT |
| STF-118804 is a highly specific NAMPT inhibitor. | ||
| M4970 | STF-31 | GLUT |
| STF-31 is a selective glucose transporter GLUT1 inhibitor, with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. | ||
| M8901 | CHS-828 | NAMPT |
| GMX1778 | ||
| CHS-828 (GMX1778) is a potent and specific inhibitor of NAMPT with IC50 and Kd value of <25 nM and 120 nM, respectively. | ||
| M9528 | KPT-9274 | PAK |
| PAK4-IN-1 | ||
| KPT-9274, also known as PAK4-IN-1, is a potent, selective and dual PAK4/NAMPT inhibitor with IC50s of less than 100 and 120 nM, respectively. | ||
| M9762 | GNE-617 | NAMPT |
| GNE617 | ||
| GNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. | ||
| M11013 | SBI-797812 | NAMPT |
| SBI-797812 is an activator of NAMPT that is structurally similar to active site-directed NAMPT inhibitors, preventing these inhibitors from binding to NAMPT. SBI-797812 transforms NAMPT into a "super catalyst" that generates NMN more efficiently. | ||
| M14476 | GNE-617 hydrochloride | NAMPT |
| GNE-617 hydrochloride is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer. | ||
| M20823 | OT-82 | NAMPT |
| OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03 nM in non-HP cancer cells and 2.89 nM in HP cancer cells, respectively. | ||
| M27930 | GPP78 | NAMPT |
| CAY10618 | ||
| GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects. | ||
| M28254 | GNE-618 | NAMPT |
| GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity. | ||
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