| Cat.No. | Name | Information |
|---|---|---|
| M14476 | GNE-617 hydrochloride | GNE-617 hydrochloride is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer. |
| M11013 | SBI-797812 | SBI-797812 is an activator of NAMPT that is structurally similar to active site-directed NAMPT inhibitors, preventing these inhibitors from binding to NAMPT. SBI-797812 transforms NAMPT into a "super catalyst" that generates NMN more efficiently. |
| M9762 | GNE-617 | GNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. |
| M9130 | LSN3154567 | LSN3154567 (also known as Nampt-IN-1) is a potent and elective NAMPT inhibitor, inhibits purified NAMPT with an IC50 of 3.1 nM. |
| M8901 | CHS-828 | CHS-828 (GMX1778) is a potent and specific inhibitor of NAMPT with IC50 and Kd value of <25 nM and 120 nM, respectively. |
| M3144 | P7C3 | P7C3 is an orally bioavailable and blood-brain barrier penetrant aminopropyl carbazole, with neuroprotective effects. P7C3 exerts its proneurogenic activity by protecting newborn neurons from apoptosis. P7C3 also enhances learning and memory in aged rats. |
| M3033 | STF-118804 | STF-118804 is a highly specific NAMPT inhibitor. |
| M56726 | JGB-1-155 | JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 μM. |
| M56725 | Nampt activator-2 | Nampt activator-2 is a potent NAMPT activator, with EC50 of 0.023 μM. |
| M56724 | Teglarinad chloride | Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). |
| M42530 | NAMPT degrader-3 | NAMPT degrader-3 is a NAMPT degrader, depending on VHL- and proteasome manner. |
| M42529 | Nampt activator-3 | NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. |
| M29654 | Nampt-IN-8 | Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS. |
| M28254 | GNE-618 | GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity. |
| M27930 | GPP78 | GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects. |
| M20823 | OT-82 | OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03 nM in non-HP cancer cells and 2.89 nM in HP cancer cells, respectively. |
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