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OT-82

Cat. No. M20823

All AbMole products are for research use only, cannot be used for human consumption.

OT-82 Structure

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Quality Control & Documentation
Biological Activity

OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.

Chemical Information
Molecular Weight 424.47
Formula C26H21FN4O
CAS Number 1800487-55-1
Solubility (25°C) DMSO 85 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yichen Wei, et al. Front Pharmacol. Review of various NAMPT inhibitors for the treatment of cancer

[2] Anna E Gibson, et al. Oncogenesis. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma

[3] Lioubov Korotchkina, et al. Leukemia. OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis

[4] Klaartje Somers, et al. Leukemia. Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia

Related NAMPT Products
JGB-1-155 

JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 μM.

Nampt activator-2 

Nampt activator-2 is a potent NAMPT activator, with EC50 of 0.023 μM.

Teglarinad chloride

Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor).

NAMPT degrader-3

NAMPT degrader-3 is a NAMPT degrader, depending on VHL- and proteasome manner.

Nampt activator-3

NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM.

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Abmole Inhibitor Catalog




Keywords: OT-82 supplier, NAMPT, inhibitors, activators

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