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Glabrescione B

Cat. No. M45268

All AbMole products are for research use only, cannot be used for human consumption.

Glabrescione B Structure

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Biological Activity

Glabrescione B is a selective GLI1 inhibitor that impairs Gli1 activity by interfering with Gli1-DNA interactions. In addition, Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells and suppresses the self-renewal capacity and clonogenic ability of tumor-derived stem cells.

Chemical Information
Molecular Weight 450.52
Formula C27H30O6
CAS Number 65893-94-9
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Fabio Buonsenso, et al. Int J Mol Sci. Exploring the Assembly of Resorc[4]arenes for the Construction of Supramolecular Nano-Aggregates

[2] Paola Infante, et al. Cancer Lett. Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma

[3] Giuseppina D'Alessandro, et al. Cell Commun Signal. 1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma

[4] Masaru Katoh. Clin Sci (Lond). Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers

[5] Cinzia Ingallina, et al. Nanomedicine (Lond). Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro

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Keywords: Glabrescione B supplier, Gli, inhibitors, activators

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