All AbMole products are for research use only, cannot be used for human consumption.
GANT58 is a cell-permeable GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.
Antioxidants (Basel). 2022 Nov 16;11(11):2265.
Hedgehog Signalling Contributes to Trauma-Induced Tendon Heterotopic Ossification and Regulates Osteogenesis through Antioxidant Pathway in Tendon-Derived Stem Cells
GANT58 purchased from AbMole
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Source | Biochimie (2014). Figure 3. GANT58 |
| Method | CCK8 assays | |
| Cell Lines | T-ALL cells | |
| Concentrations | 5 and 10 μM | |
| Incubation Time | 48 h | |
| Results | Furthermore, incubation of CCRFeCEM with 10 μM GANT58 for 48 h caused an increase in the percentage of cells in G1 and S phase and a decrease in the percentage of cells in G2/M phase relative to controls |
| Molecular Weight | 392.48 |
| Formula | C24H16N4S |
| CAS Number | 64048-12-0 |
| Solubility (25°C) | DMSO 20 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Gli Products |
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| GLI antagonist-1
GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. In addition, GLI antagonist-1 has antiproliferative activity by reducing GLI1 mRNA expression and dose-dependently inhibiting colony formation. |
| Glabrescione B
Glabrescione B is a selective GLI1 inhibitor that impairs Gli1 activity by interfering with Gli1-DNA interactions. In addition, Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells and suppresses the self-renewal capacity and clonogenic ability of tumor-derived stem cells. |
| GANT61
GANT61 is a Gli1 and Gli2 inhibitor targeting the Hedgehog/GLi pathway that inhibits GLI1- and GLI2-induced transcription with an IC50 of 5 μM. In addition, GANT61 selectively acts on the transcription of other pathways such as TNF and glucocorticoid receptor genes. |
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Products are for research use only. Not for human use. We do not sell to patients.
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