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Gemigliptin

Cat. No. M20841

All AbMole products are for research use only, cannot be used for human consumption.

Gemigliptin Structure
Synonym:

Zemiglo, LC15-0444

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Quality Control & Documentation
Biological Activity

Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.

Chemical Information
Molecular Weight 489.36
Formula C18H19F8N5O2
CAS Number 911637-19-9
Solubility (25°C) DMSO 98 mg/mL
Water 12 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Giang Nguyen, et al. Endocrinol Metab (Seoul). Gemigliptin Alleviates Succinate-Induced Hepatic Stellate Cell Activation by Ameliorating Mitochondrial Dysfunction

[2] Nami Lee, et al. J Immunol Res. Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF- κ B, MKK7/JNK, and JAK2/STAT1 Signalling Pathways

[3] Wan Seok Kang, et al. Biomed Pharmacother. Gemigliptin suppresses salivary dysfunction in streptozotocin-induced diabetic rats

[4] Oak-Kee Hong, et al. Endocrinol Metab (Seoul). Gemigliptin Inhibits Interleukin-1β-Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway

[5] Manish Gutch, et al. Indian J Endocrinol Metab. Gemigliptin: Newer Promising Gliptin for Type 2 Diabetes Mellitus

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Keywords: Gemigliptin, Zemiglo, LC15-0444 supplier, Dipeptidyl Peptidase, inhibitors, activators

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