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FTIDC 

Cat. No. M30781

All AbMole products are for research use only, cannot be used for human consumption.

FTIDC  Structure

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Quality Control & Documentation
Biological Activity

FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1.

Chemical Information
Molecular Weight 358.41
Formula C18H23FN6O
CAS Number 873551-53-2
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder -20°C
References

[1] Hilary Highfield Nickols, et al. Neurobiol Dis. Development of allosteric modulators of GPCRs for treatment of CNS disorders

[2] Gentaroh Suzuki, et al. J Pharmacol Sci. Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse brain with in vivo activity of allosteric mGluR1 antagonists

[3] Akio Satow, et al. J Pharmacol Exp Ther. Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allost䲧癐Ỵ癑㧀癏羹瘸盋晸ƘƌƘÐ�瘺嶁瘶Ѐ瑖抩䀹⹜ࢹƘÐèࢹ彿抪奋抪巫抪䬄ࢹ嫼ࢹ彿抪嫰ࢹ塚抪嫼ࢹꍈ抯⹜ࢹ學抪漸抯圔抪⹜ࢹ圞抪圭抪䀹魸瘾ƌ ƌ憠皻Ɖ㪐݋䓲瘶皼盋㪐݋ƌ 㪐݋Ð�瘺㪐݋€䀹㪔

[4] Hirohiko Hikichi, et al. Eur J Pharmacol. Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor

[5] Gentaroh Suzuki, et al. J Pharmacol Exp Ther. Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)

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  Catalog
Abmole Inhibitor Catalog




Keywords: FTIDC  supplier, GluR, inhibitors, activators

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