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Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.
| Molecular Weight | 908.88 |
| Formula | C23H52N6O25S3 |
| CAS Number | 4146-30-9 |
| Form | Solid |
| Solubility (25°C) | Water 200 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] W I SHEDDEN. Br Med J. FRAMYCETIN AND THE STAPHYLOCOCCUS
[4] No authors listed. S Afr Med J. Framycetin sulphate
[5] T Midtvedt. Tidsskr Nor Laegeforen. [Framycetin=Neomycin]
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