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Forodesine hydrochloride is a potent and orally active transition-state analog inhibitor of purine nucleoside phosphorylase. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels, acts as a potent human lymphocyte proliferation inhibitor.
At a single dose of 10 mg/kg in mice, Forodesine elevates dGuo to approximately 5 μM. In the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model, Forodesine is effective in prolonging the life span 2-fold or more.
| Molecular Weight | 302.71 |
| Formula | C11H15ClN4O4 |
| CAS Number | 284490-13-7 |
| Form | Solid |
| Solubility (25°C) | Water 15 mg/mL DMSO 9 mg/mL |
| Storage | -20°C, sealed |
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