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Cat. No. M2710
FMK Structure

RSK2 kinase inhibitor

Size Price Availability
10mM*1mL USD 225  USD225 Out of stock
5mg USD 220  USD220 Out of stock
10mg USD 334  USD334 Out of stock
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Quality Control & Documentation
Biological Activity

FMK is a potent and selective inhibitor of p90 ribosomal protein S6 kinaseRSK2 (wt) with IC50 of 15 nM, >600- and 200-fold selectivity for RSK2 than the C436V and T493M mutants.

Chemical Information
Molecular Weight 342.37
Formula C18H19FN4O2
CAS Number 821794-92-7
Solubility (25°C) DMSO 10 mM
Storage 2-8℃, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Dharaniya Sakthivel, et al. Cellular autophagy, an unbidden effect of caspase inhibition by zVAD-fmk

[2] Sarah H Needs, et al. Off-target inhibition of NGLY1 by the polycaspase inhibitor Z-VAD-fmk induces cellular autophagy

[3] Nunzia Pagano, et al. Effect of caspase inhibitor Z-VAD-FMK on bovine sperm cryotolerance

[4] Jung-Hwa Han, et al. FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced TXNIP Expression via Regulation of ChREBP in Pancreatic β Cells

[5] Jiaqi Chu, et al. ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition

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Abmole Inhibitor Catalog

Keywords: FMK, RSK2 kinase inhibitor supplier, S6 Kinase, inhibitors, activators

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