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S6K-18

Cat. No. M20745

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S6K-18 Structure

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Quality Control & Documentation
Biological Activity

S6K-18 is a highly selective inhibitor of ribosomal protein S6 kinase beta-1 (S6K1, p70S6K, p70-S6K).

Chemical Information
Molecular Weight 358.41
Formula C17H18N4O3S
CAS Number 1265789-88-5
Solubility (25°C) DMSO 72 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related S6 Kinase Products
S6K1-IN-DG2

S6K1-IN-DG2 is a p70S6K inhibitor (IC50: < 100 nM).

BRD7389 

BRD7389 is a specific RSK family kinase inhibitor with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells.

M2698

M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity.

Bisindolylmaleimide V

Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM.

LJH685

LJH685 is a potent, ATP-competitive and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50s of 6, 5, 4 nM, respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: S6K-18 supplier, S6 Kinase, inhibitors, activators

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