Free shipping on all orders over $ 500

Flavokawain A

Cat. No. M10756

All AbMole products are for research use only, cannot be used for human consumption.

Flavokawain A  Structure
Synonym:

CAS# 37951-13-6

Size Price Availability Quantity
25mg USD 40  USD40 In stock
50mg USD 50  USD50 In stock
100mg USD 80  USD80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Flavokawain A is an anticarcinogenic agent, a chalcone found in kava extracts with antitumor activity. Flavokawain A induces apoptosis through Bax protein-dependent and mitochondrial-dependent apoptosis pathways. Flavokawain A has the potential to be used in bladder cancer related research.

Chemical Information
Molecular Weight 314.33
Formula C18H18O5
CAS Number 3420-72-2
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Peramaiyan Rajendran, et al. Toxins (Basel). Anti-Apoptotic Effect of Flavokawain A on Ochratoxin-A-Induced Endothelial Cell Injury by Attenuation of Oxidative Stress via PI3K/AKT-Mediated Nrf2 Signaling Cascade

[2] Hsin-Ling Yang, et al. Oxid Med Cell Longev. Suppression of LPS-Induced Inflammation by Chalcone Flavokawain A through Activation of Nrf2/ARE-Mediated Antioxidant Genes and Inhibition of ROS/NF κ B Signaling Pathways in Primary Splenocytes

[3] Kaili Wang, et al. J Pharm Biomed Anal. Flavokawain A inhibits prostate cancer cells by inducing cell cycle arrest and cell apoptosis and regulating the glutamine metabolism pathway

[4] Lifeng Niu, et al. J Ethnopharmacol. Flavokawain A inhibits Cytochrome P450 in in vitro metabolic and inhibitory investigations

[5] Xiaolin Zi, et al. Cancer Res. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice

Related Apoptosis Products
Coenzyme Q0

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance.

C6 Ceramide

C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway.

DB2115 tertahydrochloride

DB2115 tertahydrochloride is a potent inhibitor of myeloid master regulator PU.1. DB2115 tertahydrochloride has the potential for researching cancers, including hematologic cancers.

14-3-3η Protein inhibitor 1

14-3-3η Protein inhibitor 1 is a 14-3-3η protein inhibitor with a KD of 35 µM.

Deferoxamine

Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells.

  Catalog
Abmole Inhibitor Catalog




Keywords: Flavokawain A , CAS# 37951-13-6 supplier, Apoptosis, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.